diff --git a/app/backend/systemproperties.cpp b/app/backend/systemproperties.cpp
index 4c58e2b1..8026721d 100644
--- a/app/backend/systemproperties.cpp
+++ b/app/backend/systemproperties.cpp
@@ -68,12 +68,6 @@ SystemProperties::SystemProperties()
     hasDiscordIntegration = false;
 #endif
 
-#ifdef Q_OS_DARWIN
-    supportsWindowedSystemKeyCapture = false;
-#else
-    supportsWindowedSystemKeyCapture = true;
-#endif
-
     unmappedGamepads = SdlInputHandler::getUnmappedGamepads();
 
     // Populate data that requires talking to SDL. We do it all in one shot
diff --git a/app/backend/systemproperties.h b/app/backend/systemproperties.h
index 90ce31f2..0ee6541a 100644
--- a/app/backend/systemproperties.h
+++ b/app/backend/systemproperties.h
@@ -19,7 +19,6 @@ public:
     Q_PROPERTY(bool hasWindowManager MEMBER hasWindowManager CONSTANT)
     Q_PROPERTY(bool hasBrowser MEMBER hasBrowser CONSTANT)
     Q_PROPERTY(bool hasDiscordIntegration MEMBER hasDiscordIntegration CONSTANT)
-    Q_PROPERTY(bool supportsWindowedSystemKeyCapture MEMBER supportsWindowedSystemKeyCapture CONSTANT)
     Q_PROPERTY(QString unmappedGamepads MEMBER unmappedGamepads NOTIFY unmappedGamepadsChanged)
     Q_PROPERTY(int maximumStreamingFrameRate MEMBER maximumStreamingFrameRate CONSTANT)
     Q_PROPERTY(QSize maximumResolution MEMBER maximumResolution CONSTANT)
@@ -44,7 +43,6 @@ private:
     bool hasWindowManager;
     bool hasBrowser;
     bool hasDiscordIntegration;
-    bool supportsWindowedSystemKeyCapture;
     QString unmappedGamepads;
     int maximumStreamingFrameRate;
     QSize maximumResolution;
diff --git a/app/gui/SettingsView.qml b/app/gui/SettingsView.qml
index 53c99009..ec0fd28f 100644
--- a/app/gui/SettingsView.qml
+++ b/app/gui/SettingsView.qml
@@ -911,8 +911,7 @@ Flickable {
                     id: captureSysKeysCheck
                     hoverEnabled: true
                     width: parent.width
-                    text: qsTr("Capture system keyboard shortcuts") + (SystemProperties.supportsWindowedSystemKeyCapture ?
-                              "" : qsTr(" while streaming in fullscreen mode"))
+                    text: qsTr("Capture system keyboard shortcuts")
                     font.pointSize:  12
                     enabled: SystemProperties.hasWindowManager
                     checked: StreamingPreferences.captureSysKeys && SystemProperties.hasWindowManager
diff --git a/app/streaming/input/input.cpp b/app/streaming/input/input.cpp
index 74eae418..38c4c602 100644
--- a/app/streaming/input/input.cpp
+++ b/app/streaming/input/input.cpp
@@ -171,6 +171,10 @@ SdlInputHandler::SdlInputHandler(StreamingPreferences& prefs, NvComputer*, int s
     }
 #endif
 
+#ifdef Q_OS_DARWIN
+    CGSGetGlobalHotKeyOperatingMode(_CGSDefaultConnection(), &m_OldHotKeyMode);
+#endif
+
     // Initialize the gamepad mask with currently attached gamepads to avoid
     // causing gamepads to unexpectedly disappear and reappear on the host
     // during stream startup as we detect currently attached gamepads one at a time.
@@ -240,6 +244,10 @@ SdlInputHandler::~SdlInputHandler()
     SDL_DestroyCond(m_ClipboardHasData);
     SDL_DestroyMutex(m_ClipboardLock);
 
+#ifdef Q_OS_DARWIN
+    CGSSetGlobalHotKeyOperatingMode(_CGSDefaultConnection(), m_OldHotKeyMode);
+#endif
+
 #if !SDL_VERSION_ATLEAST(2, 0, 9)
     SDL_QuitSubSystem(SDL_INIT_HAPTIC);
     SDL_assert(!SDL_WasInit(SDL_INIT_HAPTIC));
@@ -319,11 +327,28 @@ void SdlInputHandler::notifyFocusLost()
         setCaptureActive(false);
     }
 
+#ifdef Q_OS_DARWIN
+    if (m_CaptureSystemKeysEnabled) {
+        // Stop capturing system keys on focus loss
+        CGSSetGlobalHotKeyOperatingMode(_CGSDefaultConnection(), m_OldHotKeyMode);
+    }
+#endif
+
     // Raise all keys that are currently pressed. If we don't do this, certain keys
     // used in shortcuts that cause focus loss (such as Alt+Tab) may get stuck down.
     raiseAllKeys();
 }
 
+void SdlInputHandler::notifyFocusGained()
+{
+#ifdef Q_OS_DARWIN
+    if (m_CaptureSystemKeysEnabled) {
+        // Start capturing system keys again on focus gain
+        CGSSetGlobalHotKeyOperatingMode(_CGSDefaultConnection(), CGSGlobalHotKeyDisable);
+    }
+#endif
+}
+
 bool SdlInputHandler::isCaptureActive()
 {
     if (SDL_GetRelativeMouseMode()) {
@@ -350,10 +375,6 @@ bool SdlInputHandler::isSystemKeyCaptureActive()
             && (windowFlags & SDL_WINDOW_KEYBOARD_GRABBED)
 #else
             && (windowFlags & SDL_WINDOW_INPUT_GRABBED)
-#endif
-#ifdef Q_OS_DARWIN
-            // Darwin only supports full-screen system key capture
-            && (windowFlags & SDL_WINDOW_FULLSCREEN)
 #endif
             ;
 }
@@ -383,6 +404,10 @@ void SdlInputHandler::setCaptureActive(bool active)
             if (SDL_GetWindowFlags(m_Window) & SDL_WINDOW_FULLSCREEN) {
                 SDL_SetWindowGrab(m_Window, SDL_TRUE);
             }
+#endif
+#ifdef Q_OS_DARWIN
+            // SDL doesn't support this private macOS API
+            CGSSetGlobalHotKeyOperatingMode(_CGSDefaultConnection(), CGSGlobalHotKeyDisable);
 #endif
         }
 
@@ -440,6 +465,11 @@ void SdlInputHandler::setCaptureActive(bool active)
         // Allow the cursor to leave the bounds of our window again.
         SDL_SetWindowGrab(m_Window, SDL_FALSE);
 #endif
+
+#ifdef Q_OS_DARWIN
+        // SDL doesn't support this private macOS API
+        CGSSetGlobalHotKeyOperatingMode(_CGSDefaultConnection(), m_OldHotKeyMode);
+#endif
     }
 }
 
diff --git a/app/streaming/input/input.h b/app/streaming/input/input.h
index 01b997a4..823f502d 100644
--- a/app/streaming/input/input.h
+++ b/app/streaming/input/input.h
@@ -29,6 +29,25 @@ struct GamepadState {
     unsigned char lt, rt;
 };
 
+#ifdef Q_OS_DARWIN
+#include <CoreGraphics/CGError.h>
+extern "C" {
+    typedef int CGSConnection;
+    typedef enum {
+        CGSGlobalHotKeyEnable = 0,
+        CGSGlobalHotKeyDisable = 1,
+    } CGSGlobalHotKeyOperatingMode;
+
+    extern CGSConnection _CGSDefaultConnection(void);
+
+    extern CGError CGSGetGlobalHotKeyOperatingMode(CGSConnection connection,
+                                                   CGSGlobalHotKeyOperatingMode* mode);
+
+    extern CGError CGSSetGlobalHotKeyOperatingMode(CGSConnection connection,
+                                                   CGSGlobalHotKeyOperatingMode mode);
+}
+#endif
+
 #define MAX_GAMEPADS 4
 #define MAX_FINGERS 2
 
@@ -79,6 +98,8 @@ public:
 
     void notifyFocusLost();
 
+    void notifyFocusGained();
+
     bool isCaptureActive();
 
     bool isSystemKeyCaptureActive();
@@ -167,6 +188,10 @@ private:
     bool m_CaptureSystemKeysEnabled;
     int m_MouseCursorCapturedVisibilityState;
 
+#ifdef Q_OS_DARWIN
+    CGSGlobalHotKeyOperatingMode m_OldHotKeyMode;
+#endif
+
     struct {
         KeyCombo keyCombo;
         SDL_Keycode keyCode;
diff --git a/app/streaming/session.cpp b/app/streaming/session.cpp
index 67ee0c0d..fc0013c0 100644
--- a/app/streaming/session.cpp
+++ b/app/streaming/session.cpp
@@ -522,15 +522,6 @@ bool Session::initialize()
         break;
     }
 
-#ifdef Q_OS_DARWIN
-    // macOS behaves as if we're capturing system keys when
-    // we enter "real" full-screen mode, so use standard
-    // full-screen as our full-screen flag when capturing keys.
-    if (m_Preferences->captureSysKeys) {
-        m_FullScreenFlag = SDL_WINDOW_FULLSCREEN;
-    }
-#endif
-
 #if !SDL_VERSION_ATLEAST(2, 0, 11)
     // HACK: Using a full-screen window breaks mouse capture on the Pi's LXDE
     // GUI environment. Force the session to use windowed mode (which won't
@@ -1345,6 +1336,7 @@ void Session::exec(int displayOriginX, int displayOriginY)
                 if (m_Preferences->muteOnFocusLoss) {
                     m_AudioMuted = false;
                 }
+                m_InputHandler->notifyFocusGained();
                 break;
             case SDL_WINDOWEVENT_LEAVE:
                 m_InputHandler->notifyMouseLeave();